RNA G-quadruplex structures control ribosomal protein production

Journal article

Guanine quadruplexes (G4s) are nucleic acid structures exhibiting a complex structural behavior and exerting crucial biological functions in both cells and viruses. The specific interactions of peptides with G4s, as well as an understanding of the factors driving the specific recognition are important for the rational design of both therapeutic and diagnostic agents. In this review, we examine the most important studies dealing with the interactions between G4s and peptides, highlighting the strengths and limitations of current analytic approaches. We also show how the combined use of high-level molecular simulation techniques and experimental spectroscopy is the best avenue to design specifically tuned and selective peptides, thus leading to the control of important biological functions

Authors: Varshney, D; Cuesta, SM; Herdy, B; Abdullah, UB; Tannahill, D

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Research
• Journal: Scientific Reports
• Volume: 11
• Issue: 1
• Pages: 22735-22735
• Article number: 22735
• Publication date: 2021-11-23
• DOI: 10.1038/s41598-021-01847-6
• EISSN: 2045-2322
• ISSN: 2045-2322
• Language: English
• Keywords: RNA; 5.8S ribosomal RNA; Genetics; Transcriptome; Gene expression; Cell biology; Ribosomal RNA; Non-coding RNA; Ribosome; Gene; Riboswitch; Translation (biology); Biology; Small nucleolar RNA; Ribosomal protein; RNA-binding protein; Messenger RNA; Computational biology; Protein biosynthesis