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Population pharmacokinetics of the antimalarial amodiaquine: A pooled analysis to optimize dosing

Abstract:

Amodiaquine plus artesunate is the recommended antimalarial treatment in many malaria-endemic countries. However, pediatric doses are largely based on a linear extrapolation from adult doses. We pooled data from previously published studies on the pharmacokinetics of amodiaquine, to optimize the dose across all age groups. Adults and children with uncomplicated malaria received daily weight-based doses of amodiaquine or artesunate-amodiaquine over three days. Plasma concentration-time profile...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/aac.02193-17

Authors


Workman, L More by this author
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Bill and Melinda Gates Foundation More from this funder
Basel Stadt More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
62
Issue:
10
Pages:
e02193-17
Publication date:
2018-07-23
Acceptance date:
2018-07-23
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pubs id:
pubs:891874
URN:
uri:9f6c0b1d-8168-49bc-8e82-bf37f711f866
UUID:
uuid:9f6c0b1d-8168-49bc-8e82-bf37f711f866
Local pid:
pubs:891874

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