BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire
Proper temporal epigenetic regulation of gene expression is essential for cell fate determination and tissue development. The Bromodomain-containing Protein-4 (BRD4) was previously shown to control the transcription of defined subsets of genes in various cell systems. In this study we examined the role of BRD4 in promoting lineage-specific gene expression and show that BRD4 is essential for osteoblast differentiation. Genome-wide analyses demonstrate that BRD4 is recruited to the transcriptio...Expand abstract
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Copyright © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.
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