Journal article icon

Journal article

BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire

Abstract:

Proper temporal epigenetic regulation of gene expression is essential for cell fate determination and tissue development. The Bromodomain-containing Protein-4 (BRD4) was previously shown to control the transcription of defined subsets of genes in various cell systems. In this study we examined the role of BRD4 in promoting lineage-specific gene expression and show that BRD4 is essential for osteoblast differentiation. Genome-wide analyses demonstrate that BRD4 is recruited to the transcriptio...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1093/nar/gkw826

Authors


Expand authors...
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
45
Issue:
1
Pages:
127-141
Publication date:
2016-09-19
Acceptance date:
2016-09-08
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pubs id:
pubs:646039
URN:
uri:9f60a444-22df-4c91-b013-c2047ee38e9e
UUID:
uuid:9f60a444-22df-4c91-b013-c2047ee38e9e
Local pid:
pubs:646039
Paper number:
1
Language:
English

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP