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A phase 2b randomised trial of the candidate malaria vaccines FP9 ME-TRAP and MVA ME-TRAP among children in Kenya

Abstract:

OBJECTIVE: The objective was to measure the efficacy of the vaccination regimen FFM ME-TRAP in preventing episodes of clinical malaria among children in a malaria endemic area. FFM ME-TRAP is sequential immunisation with two attenuated poxvirus vectors (FP9 and modified vaccinia virus Ankara), which both deliver the pre-erythrocytic malaria antigen construct multiple epitope-thrombospondin-related adhesion protein (ME-TRAP). DESIGN: The trial was randomised and double-blinded. SETTING: The s...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pctr.0010029

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Mwacharo, J More by this author
Milligan, P More by this author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Clinical Trials Journal website
Volume:
1
Issue:
6
Pages:
e29
Publication date:
2006-10-20
Acceptance date:
2006-09-01
DOI:
EISSN:
1555-5887
ISSN:
1555-5887
URN:
uuid:9f5112d0-733e-4026-a2f6-5e153120554d
Source identifiers:
40290
Local pid:
pubs:40290
Language:
English
Keywords:

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