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Spontaneous orofacial dyskinesias in a captive cynomolgus monkey: implications for tardive dyskinesia.

Abstract:

We describe a syndrome of spontaneous orofacial dyskinesias and cage stereotypies in a singly housed adult cynomolgus monkey never previously exposed to neuroleptic drugs. Abnormal movements were readily suppressed by acute treatment with haloperidol (0.03-0.24 mg/kg i.m.) or SCH23390 (0.05-0.2 mg/kg i.m.) but not by physostigmine (0.005-0.04 mg/kg i.m.) or scopolamine (0.0025-0.04 mg/kg i.m.). The symptomatology and response to pharmacological manipulations was indistinguishable from that pr...

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Publication status:
Published

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Publisher copy:
10.1002/mds.870050410

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
Journal:
Movement disorders : official journal of the Movement Disorder Society
Volume:
5
Issue:
4
Pages:
314-318
Publication date:
1990-01-01
DOI:
EISSN:
1531-8257
ISSN:
0885-3185
URN:
uuid:9f368475-4056-4947-951e-afeca77da950
Source identifiers:
19159
Local pid:
pubs:19159

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