Spontaneous orofacial dyskinesias in a captive cynomolgus monkey: implications for tardive dyskinesia.

Journal article

We describe a syndrome of spontaneous orofacial dyskinesias and cage stereotypies in a singly housed adult cynomolgus monkey never previously exposed to neuroleptic drugs. Abnormal movements were readily suppressed by acute treatment with haloperidol (0.03-0.24 mg/kg i.m.) or SCH23390 (0.05-0.2 mg/kg i.m.) but not by physostigmine (0.005-0.04 mg/kg i.m.) or scopolamine (0.0025-0.04 mg/kg i.m.). The symptomatology and response to pharmacological manipulations was indistinguishable from that previously attributed to chronic neuroleptic treatment in primates. Our findings indicate that neuroleptic-induced tardive dyskinesias in most primate studies have not been clearly demonstrated.

Authors: Rupniak, N; Tye, S; Steventon, M; Boyce, S; Iversen, S

• Publication status: Published
• Journal: Movement disorders : official journal of the Movement Disorder Society
• Volume: 5
• Issue: 4
• Pages: 314-318
• Publication date: 1990-01-01
• DOI: 10.1002/mds.870050410
• EISSN: 1531-8257
• ISSN: 0885-3185
• Language: English
• Keywords: Physostigmine; Benzazepines; Animals; Stereotyped Behavior; Dyskinesia, Drug-Induced; Movement Disorders; Haloperidol; Scopolamine; Disease Models, Animal; Facial Muscles; Dose-Response Relationship, Drug; Macaca fascicularis; Mastication; Facial Expression