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Macrophage polarization contributes to local inflammation and structural change in the multifidus muscle after intervertebral disc injury

Abstract:
Purpose Intervertebral disk (IVD) lesion and its subsequent degeneration have a profound effect on the multifidus muscle. The subacute/early chronic phase of multifidus remodeling after IVD lesion has been proposed to be regulated by inflammatory processes. The balance between pro-inflammatory (M1) and anti-inflammatory (M2) macrophages plays an important role in maintaining tissue integrity after injury. The localization, polarization of macrophage subtypes and their mediati... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1007/s00586-018-5652-7

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
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Grant:
APP1002190
ID631717
APP1004032
APP1002190
ID631717
APP1004032
Publisher:
Springer Verlag Publisher's website
Journal:
European Spine Journal Journal website
Volume:
27
Issue:
8
Pages:
1744–1756
Publication date:
2018-06-12
Acceptance date:
2018-06-01
DOI:
EISSN:
1432-0932
ISSN:
0940-6719
Pubs id:
pubs:860002
URN:
uri:9f1b9403-33b4-463f-9939-4f462643f4bd
UUID:
uuid:9f1b9403-33b4-463f-9939-4f462643f4bd
Local pid:
pubs:860002

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