Repeated administration of subconvulsant doses of GABA antagonist drugs. II. Effect on monoamine-mediated behaviour.

Journal article

The effect on monoamine-medical behaviour of repeated daily subconvulsive doses of the GABA antagonist drugs pentylenetetrazol (PTZ) (30 mg/kg for 8 days), picrotoxin (5 mg/kg for 4 days) and bicuculline (3.5 mg/kg for 16 days) was investigated. None of the drugs, administered chronically, increased behavioural responses to the 5-hydroxytryptamine agonist quipazine (25 mg/kg), and neither picrotoxin nor bicuculline altered the locomotor response to the dopamine agonist apomorphine (AP) (0.1 mg/kg). By contrast, repeated doses of PTZ increased the locomotor response to AP, and also increased circling responses to both AP (0.5 mg/kg) and methamphetamine (2.0 mg/kg) in unilateral nigrostriatal-lesioned rats.

Authors: Cowen, P; Nutt, D; Batts, C; Green, A; Heal, D

• Publication status: Published
• Publisher: Springer-Verlag
• Journal: Psychopharmacology
• Volume: 76
• Issue: 1
• Pages: 88-91
• Publication date: 1982-01-01
• DOI: 10.1007/bf00430763
• EISSN: 1432-2072
• ISSN: 0033-3158
• Language: English
• Keywords: Kindling, Neurologic; Animals; Motor Activity; Humans; Pentylenetetrazole; GABA Antagonists; Methamphetamine; Rats, Inbred Strains; Receptors, Serotonin; Picrotoxin; Quipazine; Apomorphine; Bicuculline; Behavior, Animal; Receptors, Dopamine; Male; Stereotyped Behavior; Rats