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Repeated administration of subconvulsant doses of GABA antagonist drugs. II. Effect on monoamine-mediated behaviour.

Abstract:

The effect on monoamine-medical behaviour of repeated daily subconvulsive doses of the GABA antagonist drugs pentylenetetrazol (PTZ) (30 mg/kg for 8 days), picrotoxin (5 mg/kg for 4 days) and bicuculline (3.5 mg/kg for 16 days) was investigated. None of the drugs, administered chronically, increased behavioural responses to the 5-hydroxytryptamine agonist quipazine (25 mg/kg), and neither picrotoxin nor bicuculline altered the locomotor response to the dopamine agonist apomorphine (AP) (0.1 m...

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Publication status:
Published

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Publisher copy:
10.1007/bf00430763

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Publisher:
Springer-Verlag
Journal:
Psychopharmacology
Volume:
76
Issue:
1
Pages:
88-91
Publication date:
1982
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:9eea3d05-42e7-416f-99f5-6cf09929ceac
Source identifiers:
185967
Local pid:
pubs:185967

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