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Early clinical trials with a new tuberculosis vaccine, MVA85A, in tuberculosis-endemic countries: issues in study design.

Abstract:

Tuberculosis remains a substantial global health problem despite effective drug treatments. The efficacy of BCG, the only available vaccine, is variable, especially in tuberculosis-endemic regions. Recent advances in the development of new vaccines against tuberculosis mean that the first of these are now entering into early clinical trials. A recombinant modified vaccinia virus Ankara expressing a major secreted antigen from Mycobacterium tuberculosis, antigen 85A, was the first new tubercul...

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Publication status:
Published

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Authors


Ibanga, HB More by this author
Brookes, RH More by this author
Owiafe, PK More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
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Journal:
The Lancet. Infectious diseases
Volume:
6
Issue:
8
Pages:
522-528
Publication date:
2006-08-05
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
URN:
uuid:9ecb9424-8d34-4cea-854e-bbd159cf42dc
Source identifiers:
40007
Local pid:
pubs:40007

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