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Journal article

Separating and visualising protein assemblies by means of preparative mass spectrometry and microscopy.

Abstract:

Many multi-protein assemblies exhibit characteristics which hamper their structural and dynamical characterization. These impediments include low copy number, heterogeneity, polydispersity, hydrophobicity, and intrinsic disorder. It is becoming increasingly apparent that both novel and hybrid structural biology approaches need to be developed to tackle the most challenging targets. Nanoelectrospray mass spectrometry has matured over the last decade to enable the elucidation of connectivity an...

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Publication status:
Published

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Publisher copy:
10.1016/j.jsb.2010.03.004

Authors


Benesch, JL More by this author
Ruotolo, BT More by this author
Simmons, DA More by this author
Barrera, NP More by this author
Morgner, N More by this author
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Journal:
Journal of structural biology
Volume:
172
Issue:
2
Pages:
161-168
Publication date:
2010-11-05
DOI:
EISSN:
1095-8657
ISSN:
1047-8477
URN:
uuid:9e96bd53-c7c4-429c-82d5-7a03fa59bf43
Source identifiers:
59337
Local pid:
pubs:59337

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