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How to minimize dye-induced perturbations while studying biomembrane structure and dynamics: PEG linkers as a rational alternative

Abstract:

Organic dye-tagged lipid analogs are essential for many fluorescence-based investigations of complex membrane structures, especially when using advanced microscopy approaches. However, lipid analogs may interfere with membrane structure and dynamics, and it is not obvious that the properties of lipid analogs would match those of non-labeled host lipids. In this work, we bridged atomistic simulations with super-resolution imaging experiments and biomimetic membranes to assess the performance o...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.bbamem.2018.07.003

Authors


Mobarak, E More by this author
Javanainen, M More by this author
Honigmann, A More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM - Investigative Medicine Division
ORCID:
0000-0002-4915-388X
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Funding agency for:
Sezgin, E
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Funding agency for:
Sezgin, E
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Funding agency for:
Sezgin, E
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Funding agency for:
Sezgin, E
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Publisher:
Elsevier Publisher's website
Journal:
Biochimica et Biophysica Acta (BBA) - Biomembranes Journal website
Volume:
1860
Issue:
11
Pages:
2436-2445
Publication date:
2018-07-18
Acceptance date:
2018-07-09
DOI:
EISSN:
1879-2642
ISSN:
0005-2736
Pubs id:
pubs:891326
URN:
uri:9e792c6a-920f-4bb8-804d-af1b936db222
UUID:
uuid:9e792c6a-920f-4bb8-804d-af1b936db222
Local pid:
pubs:891326

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