Journal article : Review
CACNA1C (CaV1.2) and other L-type calcium channels in the pathophysiology and treatment of psychiatric disorders: advances from functional genomics and pharmacoepidemiology
- Abstract:
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A role for voltage-gated calcium channels (VGCCs) in psychiatric disorders has long been postulated as part of a broader involvement of intracellular calcium signalling. However, the data were inconclusive and hard to interpret. We review three areas of research that have markedly advanced the field. First, there is now robust genomic evidence that common variants in VGCC subunit genes, notably CACNA1C which encodes the L-type calcium channel (LTCC) CaV1.2 subunit, are trans...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 757.2KB, Terms of use)
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- Publisher copy:
- 10.1016/j.neuropharm.2022.109262
Authors
Bibliographic Details
- Publisher:
- Elsevier
- Journal:
- Neuropharmacology More from this journal
- Volume:
- 220
- Article number:
- 109262
- Place of publication:
- England
- Publication date:
- 2022-09-22
- Acceptance date:
- 2022-09-17
- DOI:
- EISSN:
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1873-7064
- ISSN:
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0028-3908
- Pmid:
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36154842
Item Description
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1280326
- Local pid:
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pubs:1280326
- Deposit date:
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2023-01-23
Terms of use
- Copyright holder:
- Harrison et al.
- Copyright date:
- 2022
- Rights statement:
- © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license.
- Licence:
- CC Attribution (CC BY)
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