Journal article

Autophagy and immune senescence

Abstract:: With extension of the average lifespan, aging has become a heavy burden in society. Immune senescence is a key risk factor for many age-related diseases such as cancer and increased infections in the elderly, and hence has elicited much attention in recent years. As our body's guardian, the immune system maintains systemic health through removal of pathogens and damage. Autophagy is an important cellular 'clearance' process by which a cell internally delivers damaged organelles and macromolecules to lysosomes for degradation. Here, we discuss the most current knowledge of how impaired autophagy can lead to cellular and immune senescence. We also provide an overview, with examples, of the clinical potential of exploiting autophagy to delay immune senescence and/or rejuvenate immunity to treat various age-related diseases.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Zhang, H., Puleston, D., & Simon, A. (2016). Autophagy and immune senescence. Trends in Molecular Medicine, 22(8), 671–686.

MLA Style

Zhang, H, et al. “Autophagy and Immune Senescence.” Trends in Molecular Medicine, vol. 22, no. 8, 2016, pp. 671–86.

Chicago Style

Zhang, H, D Puleston, and A Simon. 2016. “Autophagy and Immune Senescence.” Trends in Molecular Medicine 22 (8): 671–86.
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Files:: TMM review to deposit.pdf

(Preview, Accepted manuscript, pdf, 1.7MB, Terms of use)

Publisher copy:: 10.1016/j.molmed.2016.06.001

Authors

+ Zhang, H More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDORMS
Sub department:: Kennedy Institute for Rheumatology
Role:: Author

+ Puleston, D More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDORMS
Sub department:: Kennedy Institute for Rheumatology
Role:: Author

+ Simon, A More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDORMS
Sub department:: Kennedy Institute for Rheumatology
Role:: Author

+ National Institute of Health Research Oxford Biomedical Research Center More from this funder

Funding agency for:: Puleston, D

+ Chinese Scholarship Council More from this funder

Funding agency for:: Zhang, H

Publisher:: Cell Press
Journal:: Trends in Molecular Medicine More from this journal
Volume:: 22
Issue:: 8
Pages:: 671-686
Publication date:: 2016-08-01
Acceptance date:: 2016-07-08
DOI:: 10.1016/j.molmed.2016.06.001
EISSN:: 1471-499X
ISSN:: 1471-4914
Pmid:: 27395769

Language:: English
Keywords:: Journal Article

Review
Pubs id:: pubs:633998
UUID:: uuid:9e6ec8b0-eb6d-4f67-b1a4-2cab11fb1ab4
Local pid:: pubs:633998
Source identifiers:: 633998
Deposit date:: 2016-09-23
ARK identifier:: ark:/29072/ora_9e6ec8b0eb6d4f67b1a42cab11fb1ab4

Terms of use

Copyright holder:: Elsevier Ltd
Copyright date:: 2016
Notes:: Copyright © 2016 Elsevier Ltd. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.molmed.2016.06.001

Licence:: CC Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

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