Journal article
c-Myc antagonises the transcriptional activity of the androgen receptor in prostate cancer affecting key gene networks.
- Abstract:
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Prostate cancer (PCa) is the most common non-cutaneous cancer in men. The androgen receptor (AR), a ligand-activated transcription factor, constitutes the main drug target for advanced cases of the disease. However, a variety of other transcription factors and signaling networks have been shown to be altered in patients and to influence AR activity. Amongst these, the oncogenic transcription factor c-Myc has been studied extensively in multiple malignancies and elevated protein levels of c-My...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.8MB)
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- Publisher copy:
- 10.1016/j.ebiom.2017.04.006
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Authors
Funding
Norwegian Cancer Society
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South-East Norway Health Authorities
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Norwegian Centre for Molecular Medicine
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Norwegian Research Council
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Norwegian Cancer Society
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- EBioMedicine Journal website
- Volume:
- 18
- Pages:
- 83-93
- Publication date:
- 2017-04-01
- Acceptance date:
- 2017-04-04
- DOI:
- EISSN:
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2352-3964
- Pmid:
-
28412251
- Source identifiers:
-
817470
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:817470
- UUID:
-
uuid:9e3b262c-6991-4e69-b56d-4e146e163d06
- Local pid:
- pubs:817470
- Deposit date:
- 2018-01-11
Terms of use
- Copyright holder:
- Crown Copyright
- Copyright date:
- 2017
- Notes:
- Crown Copyright © 2017 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- Licence:
- CC Attribution (CC BY)
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