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Journal article

c-Myc antagonises the transcriptional activity of the androgen receptor in prostate cancer affecting key gene networks.

Abstract:

Prostate cancer (PCa) is the most common non-cutaneous cancer in men. The androgen receptor (AR), a ligand-activated transcription factor, constitutes the main drug target for advanced cases of the disease. However, a variety of other transcription factors and signaling networks have been shown to be altered in patients and to influence AR activity. Amongst these, the oncogenic transcription factor c-Myc has been studied extensively in multiple malignancies and elevated protein levels of c-My...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.ebiom.2017.04.006

Authors


Barfeld, SJ More by this author
More by this author
ORCID:
0000-0003-2931-3652
Itkonen, HM More by this author
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Norwegian Cancer Society More from this funder
South-East Norway Health Authorities More from this funder
Norwegian Centre for Molecular Medicine More from this funder
Norwegian Research Council More from this funder
Norwegian Cancer Society More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
EBioMedicine Journal website
Volume:
18
Pages:
83-93
Publication date:
2017-04-05
Acceptance date:
2017-04-04
DOI:
EISSN:
2352-3964
Pubs id:
pubs:817470
URN:
uri:9e3b262c-6991-4e69-b56d-4e146e163d06
UUID:
uuid:9e3b262c-6991-4e69-b56d-4e146e163d06
Local pid:
pubs:817470

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