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Lessons from a breast cell annotation competition series for school pupils

Abstract:
Due to COVID-19 outbreaks, most school pupils have had to be home-schooled for long periods of time. Two editions of a web-based competition “Beat the Pathologists” for school age participants in the UK ran to fill up pupils’ spare time after home-schooling and evaluate their ability on contributing to AI annotation. The two editions asked the participants to annotate different types of cells on Ki67 stained breast cancer images. The Main competition was at four levels with different level of complexity. We obtained annotations of four kinds of cells entered by school pupils and ground truth from expert pathologists. In this paper, we analyse school pupils’ performance on differentiating different kinds of cells and compare their performance with two neural networks (AlexNet and VGG16). It was observed that children tend to get very good performance in tumour cell annotation with the best F1 measure 0.81 which is a metrics taking both false positives and false negatives into account. Low accuracy was achieved with F1 score 0.75 on positive non-tumour cells and 0.59 on negative non-tumour cells. Superior performance on non-tumour cell detection was achieved by neural networks. VGG16 with training from scratch achieved an F1 score over 0.70 in all cell categories and 0.92 in tumour cell detection. We conclude that non-experts like school pupils have the potential to contribute to large-scale labelling for AI algorithm development if sufficient training activities are organised. We hope that competitions like this can promote public interest in pathology and encourage participation by more non-experts for annotation.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-022-11782-9

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author


Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Volume:
12
Article number:
7792
Publication date:
2022-05-12
Acceptance date:
2022-03-21
DOI:
EISSN:
2045-2322


Language:
English
Keywords:
Pubs id:
1249522
Local pid:
pubs:1249522
Deposit date:
2022-04-05

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