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Cytoophidia respond to nutrient stress in Drosophila

Abstract:

CTP synthase (CTPsyn) is a metabolic enzyme essential for the de novo synthesis of CTP the nucleotide. CTPsyn can be compartmented into filamentous structures named cytoophidia. Cytoophidia are conserved in a wide range of species and are highly abundant in Drosophila ovaries. Here we report that cytoophidia elongate upon nutrient deprivation, CTPsyn overexpression or heat shock in Drosophila ovaries. We also show that the curvature of cytoophidia changes during apoptosis. Moreover, cytoophid...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.yexcr.2019.02.003

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
ORCID:
0000-0002-4834-8554
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Grant:
MC_UU_12021/3
MC_U137788471
Publisher:
Elsevier Publisher's website
Journal:
Experimental Cell Research Journal website
Volume:
376
Issue:
2
Pages:
159-167
Publication date:
2019-02-13
Acceptance date:
2019-02-09
DOI:
EISSN:
1090-2422
ISSN:
0014-4827
Pubs id:
pubs:975243
URN:
uri:9db3a743-9f2b-424c-83fc-65e62e68def5
UUID:
uuid:9db3a743-9f2b-424c-83fc-65e62e68def5
Local pid:
pubs:975243

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