Long-term seroprotection after an adolescent booster meningococcal serogroup C vaccination.

de Whalley, P; Snape, MD; Plested, E; Thompson, B; Nuthall, E; Omar, O; Borrow, R; Pollard, A

Journal article

Long-term seroprotection after an adolescent booster meningococcal serogroup C vaccination.

Abstract:: OBJECTIVES: To determine long-term seroprotection after serogroup C meningococcal (MenC) vaccination at the age of 9-12 years, with or without booster vaccination at the age of 13-15 years. DESIGN: Observational cohort study; follow-on from randomised study. SETTING: Participants were recruited from English secondary schools (in Oxfordshire and Buckinghamshire). PARTICIPANTS AND INTERVENTIONS: Participants were primed with MenC CRM-glycoconjugate vaccine at the age of 9-12 years in the UK routine immunisation campaign. In previous studies they were randomised at 13 to 15 years of age to receive a booster dose of MenC-CRM glycoconjugate vaccine (CRM-group) or bivalent meningococcal serogroup A/C polysaccharide vaccine (PS-group), or they received no additional doses of MenC vaccine (control group). In this follow-on study, a blood sample was obtained 11 years after primary immunisation. Of 531 individuals eligible to participate, 134 were enrolled, and 124 were included in the analysis. MAIN OUTCOME MEASURES: MenC serum bactericidal antibody (SBA) geometric mean titre; proportion of participants with SBA titre ≥8 (putative protective threshold). RESULTS: Median ages at priming, boosting and blood sampling were 10.61, 14.42 and 22.11 years, respectively. Geometric mean titres for MenC SBA were: CRM group 1373 (95% CI 954 to 1977); PS group 1024 (687 to 1526); and controls 284 (167 to 483). SBA titres ≥8 were present in 50/54 (92.6%) controls and 70/70 (100%) boosted individuals. CONCLUSIONS: The planned introduction in the UK of an adolescent booster of MenC conjugate vaccine in 2013 is likely to provide sustained protection against MenC disease. TRIAL REGISTRATION: Registered on ClinicalTrials.gov (NCT01459432).

Publication status:: Published

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APA Style

de Whalley, P., Snape, M. D., Plested, E., Thompson, B., Nuthall, E., Omar, O., Borrow, R., & Pollard, A. (2013). Long-term seroprotection after an adolescent booster meningococcal serogroup C vaccination. Archives of Disease in Childhood, 98(9), 686–691.

MLA Style

de Whalley, P., et al. “Long-Term Seroprotection after an Adolescent Booster Meningococcal Serogroup C Vaccination.” Archives of Disease in Childhood, vol. 98, no. 9, 2013, pp. 686–91.

Chicago Style

Whalley, P de, MD Snape, E Plested, B Thompson, E Nuthall, O Omar, R Borrow, and A Pollard. 2013. “Long-Term Seroprotection after an Adolescent Booster Meningococcal Serogroup C Vaccination.” Archives of Disease in Childhood 98 (9): 686–91.
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