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Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection.

Abstract:

BACKGROUND: The HLA class II molecules play a central role in the generation of human immunodeficiency virus (HIV)-specific CD4(+) T-helper cells, which are critical for the induction of cytotoxic CD8(+) T cell responses. However, little is known about the impact of HLA class II alleles on HIV disease progression. METHODS: In this study we investigated the effect of HLA class II alleles on HIV disease outcome and HIV-specific T cell responses in a cohort of 426 antiretroviral therapy-naive, H...

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Publisher copy:
10.1093/infdis/jiq122

Authors


Moodley, ES More by this author
Ramduth, D More by this author
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Journal:
The Journal of infectious diseases
Volume:
203
Issue:
6
Pages:
803-809
Publication date:
2011-03-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:9d84a1c3-205c-44c6-ab97-99e4501cf7a9
Source identifiers:
191289
Local pid:
pubs:191289

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