- Abstract:
- Fulvestrant (Faslodex®) was synthesized in four steps (35% overall yield) from 6-dehydronandrolone acetate. Catalyst controlled, room temperature, diastereoselective 1,6-addition of the zirconocene derived from commercially available 9-bromonon-1-ene was used in the key C–C bond forming step.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1039/C5CC05805H
- Publication website:
- http://pubs.rsc.org/en/content/articlelanding/2015/cc/c5cc05805h
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- Publisher:
- Royal Society of Chemistry Publisher's website
- Journal:
- Chemical Communications
- Publication date:
- 2015-08-17
- Acceptance date:
- 2015-08-17
- DOI:
- EISSN:
-
1364-548X
- ISSN:
-
1359-7345
- Subjects:
- Copyright date:
- 2015
Journal article
An alternative synthesis of the breast cancer drug fulvestrant (Faslodexs): catalyst control over C–C bond formation
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