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An alternative synthesis of the breast cancer drug fulvestrant (Faslodexs): catalyst control over C–C bond formation

Abstract:
Fulvestrant (Faslodex®) was synthesized in four steps (35% overall yield) from 6-dehydronandrolone acetate. Catalyst controlled, room temperature, diastereoselective 1,6-addition of the zirconocene derived from commercially available 9-bromonon-1-ene was used in the key C–C bond forming step.
Publication status:
Published
Peer review status:
Peer reviewed

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Department:
Department of Chemistry, University of Oxford
Role:
Author
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Department:
Department of Chemistry, University of Oxford
Role:
Author
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Chemical Communications
Publication date:
2015-08-17
Acceptance date:
2015-08-17
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
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