Journal article

An alternative synthesis of the breast cancer drug fulvestrant (Faslodexs): catalyst control over C–C bond formation

Abstract:: Fulvestrant (Faslodex®) was synthesized in four steps (35% overall yield) from 6-dehydronandrolone acetate. Catalyst controlled, room temperature, diastereoselective 1,6-addition of the zirconocene derived from commercially available 9-bromonon-1-ene was used in the key C–C bond forming step.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Caprioglio, D., & Fletcher, S. (2015). An alternative synthesis of the breast cancer drug fulvestrant (Faslodexs): catalyst control over C–C bond formation. Chemical Communications.

MLA Style

Caprioglio, D., and S. Fletcher. “An Alternative Synthesis of the Breast Cancer Drug Fulvestrant (Faslodexs): Catalyst Control over C–C Bond Formation.” Chemical Communications, Royal Society of Chemistry, 2015.

Chicago Style

Caprioglio, D, and S Fletcher. 2015. “An Alternative Synthesis of the Breast Cancer Drug Fulvestrant (Faslodexs): Catalyst Control over C–C Bond Formation.” Chemical Communications.
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Publisher copy:: 10.1039/C5CC05805H

Publication website:: http://pubs.rsc.org/en/content/articlelanding/2015/cc/c5cc05805h

Authors

+ Caprioglio, D More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Role:: Author

+ Fletcher, S More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Role:: Author

Publisher:: Royal Society of Chemistry
Journal:: Chemical Communications More from this journal
Publication date:: 2015-08-17
Acceptance date:: 2015-08-17
DOI:: 10.1039/C5CC05805H
EISSN:: 1364-548X
ISSN:: 1359-7345

Subjects:: Chemistry
UUID:: uuid:9d7d6d0d-695f-4494-9ac6-2bcbf18d0900
Deposit date:: 2015-09-18

Terms of use

Copyright date:: 2015

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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