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Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria: A systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data

Abstract:

Background: Achieving adequate antimalarial drug exposure is essential for curing malaria. Day 7 blood or plasma lumefantrine concentrations provide a simple measure of drug exposure that correlates well with artemether-lumefantrine efficacy. However, the 'therapeutic' day 7 lumefantrine concentration threshold needs to be defined better, particularly for important patient and parasite sub-populations. Methods: The WorldWide Antimalarial Resistance Network (WWARN) conducted a large pooled ana...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12916-015-0456-7

Authors


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Bill and Melinda Gates Foundation More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
BMC Medicine Journal website
Volume:
13
Issue:
1
Publication date:
2015-01-01
DOI:
EISSN:
1741-7015
URN:
uuid:9d54a7f5-2448-4d34-8c6b-44f658c1ce4f
Source identifiers:
567710
Local pid:
pubs:567710

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