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Efficacy and safety of co-administered ivermectin plus albendazole for treating soil-transmitted helminths: A systematic review, meta-analysis and individual patient data analysis

Abstract:

Background

The soil-transmitted helminths (STH), Ascaris lumbricoides, Trichuris trichiura and hookworms, infect 1.5 billion people worldwide and cause an estimated burden of 3.3 million disability- adjusted life years (DALYs). Current control strategies focus on morbidity reduction through preventive chemotherapy (PC) but the most commonly used recommended drugs (albendazole and mebendazole) are particularly inefficacious against T. trichiura. This, together with the threat of e...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Files:
Publisher copy:
10.1371/journal.pntd.0006458

Authors


Palmeirim, MS More by this author
Hürlimann, E More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
ORCID:
0000-0002-3301-8085
Belizario, V More by this author
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Contributors

Role:
Editor
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Neglected Tropical Diseases Journal website
Volume:
12
Issue:
4
Pages:
e0006458
Publication date:
2018-04-27
Acceptance date:
2018-04-18
DOI:
EISSN:
1935-2735
ISSN:
1935-2727
Pubs id:
pubs:919287
URN:
uri:9d4680bd-2b8c-4739-83ca-7894fee8b8b5
UUID:
uuid:9d4680bd-2b8c-4739-83ca-7894fee8b8b5
Local pid:
pubs:919287

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