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Journal article

Bioavailability study of oral and intravenous OGT 719, a novel nucleoside analogue with preferential activity in the liver.

Abstract:

PURPOSE: Although oral fluoropyrimidine prodrugs are increasingly being administered in preference to intravenous nucleoside analogues in cancer chemotherapy, their activation in malignant liver tissue may be insufficient. OGT 719 (1-galactopyranosyl-5-fluorouracil) is a novel nucleoside analogue, preferentially localized in hepatocytes and hepatoma cells via the asialoglycoprotein receptor. The aim of this study was to assess the systemic bioavailability of this rationally designed drug in 1...

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Publication status:
Published

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Publisher copy:
10.1007/s002800100332

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Journal:
Cancer chemotherapy and pharmacology
Volume:
48
Issue:
3
Pages:
197-201
Publication date:
2001-09-05
DOI:
EISSN:
1432-0843
ISSN:
0344-5704
URN:
uuid:9d2d2fad-0858-448d-a55c-309d6a1acc18
Source identifiers:
131611
Local pid:
pubs:131611

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