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Journal article

Three-dimensional structures of translating ribosomes by Cryo-EM.

Abstract:

Cryo-electron microscopy and image reconstruction techniques have been used to obtain three-dimensional maps for E. coli ribosomes stalled following translation of three representative proteins. Comparisons of these electron density maps, at resolutions of between 13 and 16 A, with that of a nontranslating ribosome pinpoint specific structural differences in stalled ribosomes and identify additional material, including tRNAs and mRNA. In addition, the tunnel through the large subunit, the ant...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
Journal:
Molecular cell
Volume:
14
Issue:
1
Pages:
57-66
Publication date:
2004-04-01
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Source identifiers:
27194
Language:
English
Keywords:
Pubs id:
pubs:27194
UUID:
uuid:9d102e55-5701-4209-87b8-c55678131263
Local pid:
pubs:27194
Deposit date:
2012-12-19

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