PfEMP1, polymorphism and pathogenesis.

Journal article

The virulence of Plasmodium falciparum relative to the other species of malarial parasite which infect humans is thought to be due to this parasite's ability to adhere to endothelial cells lining small blood vessels and, in some cases, to its ability to form rosettes with uninfected erythrocytes. The latter phenotype has been found more frequently in cases of severe disease. The former property means that only the younger, asexual, intra-erythrocytic forms circulate whereas the more mature de...

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Authors: Newbold, C; Craig, A; Kyes, S; Berendt, A; Snow, R

• Publication status: Published
• Journal: Annals of tropical medicine and parasitology
• Volume: 91
• Issue: 5
• Pages: 551-557
• Publication date: 1997-07-01
• DOI: 10.1080/00034989760923
• EISSN: 1364-8594
• ISSN: 0003-4983
• Language: English
• Keywords: Endothelium, Vascular; Humans; Receptors, Cell Surface; Blood Proteins; Malaria, Falciparum; Plasmodium falciparum; Membrane Proteins; Virulence; Cell Adhesion; Animals; Cell Adhesion Molecules; Polymorphism, Genetic; Protozoan Proteins; Erythrocyte Membrane