Enhanced in vivo antitumor efficacy of dual-functional peptide-modified docetaxel nanoparticles through tumor targeting and Hsp90 inhibition

Journal article

Although conventional anticancer drugs exhibit excellent efficacy, serious adverse effects and/or even toxicity have occurred due to their nonselectivity. Moreover, active targeting approaches have not consistently led to successful outcomes. Ligands that simultaneously possess targeting capability and exert a strong influence on intracellular signaling cascades may be expected to improve the therapeutic efficacy of active targeting nanoparticulate carriers. In this study, we screened a targe...

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Authors: Jiang, Y; Yang, N; Zhang, H; Sun, B; Hou, C

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: Journal of Controlled Release
• Volume: 221
• Pages: 26-36
• Place of publication: Netherlands
• Publication date: 2015-11-28
• Acceptance date: 2015-11-27
• DOI: 10.1016/j.jconrel.2015.11.029
• EISSN: 1873-4995
• ISSN: 0168-3659
• Pmid: 26643616
• Language: English
• Keywords: nanoparticles; targeting peptide; lung cancer; heat shock protein 90; targeting therapy