Journal article

Human histone demethylase KDM6B can catalyse sequential oxidations

Abstract:: Jumonji domain-containing demethylases (JmjC-KDMs) catalyse demethylation of Nε-methylated lysines on histones and play important roles in gene regulation. We report selectivity studies on KDM6B (JMJD3), a disease-relevant JmjC-KDM, using synthetic lysine analogues. The results unexpectedly reveal that KDM6B accepts multiple Nε-alkylated lysine analogues, forming alcohol, aldehyde and carboxylic acid products.

Publication status:: Published

Peer review status:: Peer reviewed

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Share
Cite

Cite this record

APA Style

Hopkinson, R., Langley, G., Belle, R., Walport, L., Dunne, K., Münzel, M., Salah, E., Kawamura, A., Claridge, T., & Schofield, C. (2018). Human histone demethylase KDM6B can catalyse sequential oxidations. Chemical Communications, 54(57), 7975–7978.

MLA Style

Hopkinson, R, et al. “Human Histone Demethylase KDM6B Can Catalyse Sequential Oxidations.” Chemical Communications, vol. 54, no. 57, 2018, pp. 7975–78.

Chicago Style

Hopkinson, R, G Langley, R Belle, et al. 2018. “Human Histone Demethylase KDM6B Can Catalyse Sequential Oxidations.” Chemical Communications 54 (57): 7975–78.
Print

Access Document

Files:: c8cc04057e.pdf

(Preview, Version of record, pdf, 2.2MB, Terms of use)

Publisher copy:: 10.1039/c8cc04057e

Authors

+ Hopkinson, R More by this author

Institution:: University of Oxford
Oxford college:: St Edmund Hall
Role:: Author
ORCID:: 0000-0001-7610-8163

+ Langley, G More by this author

Institution:: University of Oxford
Division:: MPLS Division
Department:: Chemistry
Role:: Author

+ Belle, R More by this author

Institution:: University of Oxford
Division:: MPLS Division
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Walport, L More by this author

Institution:: University of Oxford
Division:: MPLS Division
Department:: Chemistry
Sub department:: Organic Chemistry
Oxford college:: St Edmund Hall
Role:: Author
ORCID:: 0000-0002-3795-8365

+ Dunne, K More by this author

Role:: Author

More authors...

+ Royal Society More from this funder

Funding agency for:: Kawamura, A
Grant:: Dorothy Hodgkin Fellowship

+ European Union More from this funder

Funding agency for:: Walport, L
Grant:: Marie Skłodowska-Curie grant agreement no. 657292

+ St. Edmund Hall, Oxford More from this funder

Funding agency for:: Hopkinson, R
Grant:: William R. Miller Junior Research Fellowship

+ Systems Approaches to Biomedical Science Industrial Doctoral Centre More from this funder

Funding agency for:: Langley, G
Grant:: EP/G037280/1

+ Wellcome Trust More from this funder

Grant:: 091857/7/10/7

More funders...

Publisher:: Royal Society of Chemistry
Journal:: Chemical Communications More from this journal
Volume:: 54
Issue:: 57
Pages:: 7975-7978
Publication date:: 2018-07-02
Acceptance date:: 2018-06-06
DOI:: 10.1039/c8cc04057e
EISSN:: 1364-548X
ISSN:: 1359-7345
Pmid:: 29961803

Language:: English
Pubs id:: pubs:864214
UUID:: uuid:9cea0a11-383d-4a34-9b2f-9638240ee449
Local pid:: pubs:864214
Source identifiers:: 864214
Deposit date:: 2018-09-03
ARK identifier:: ark:/29072/ora_9cea0a11383d4a349b2f9638240ee449

Terms of use

Copyright holder:: Hopkinson et al
Copyright date:: 2018
Notes:: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Licence:: CC Attribution (CC BY)

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP