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Journal article

Functional characterization of calcium-sensing receptor mutations expressed in human embryonic kidney cells.

Abstract:

The calcium-sensing receptor (CaR) is a G-protein-coupled receptor that plays a key role in extracellular calcium ion homeostasis. We have engineered 11 CaR mutants that have been described in the disorders familial benign hypercalcemia (FBH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalcaemia (ADH), and studied their function by characterizing intracellular calcium [Ca2+]i transients in response to varying concentrations of extracellular calcium [Ca2+]o or gado...

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Publication status:
Published

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Publisher copy:
10.1172/jci118987

Authors


Pearce, SH More by this author
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Journal:
The Journal of clinical investigation
Volume:
98
Issue:
8
Pages:
1860-1866
Publication date:
1996-10-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:9cdd01a3-f9a0-430f-89d1-ed16e2d6be18
Source identifiers:
20920
Local pid:
pubs:20920

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