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Journal article

Painful and painless channelopathies.

Abstract:

The discovery of genetic variants that substantially alter an individual's perception of pain has led to a step-change in our understanding of molecular events underlying the detection and transmission of noxious stimuli by the peripheral nervous system. For example, the voltage-gated sodium ion channel Nav1.7 is expressed selectively in sensory and autonomic neurons; inactivating mutations in SCN9A, which encodes Nav1.7, result in congenital insensitivity to pain, whereas gain-of-function mu...

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Publication status:
Published

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Journal:
The Lancet. Neurology
Volume:
13
Issue:
6
Pages:
587-599
Publication date:
2014-06-05
DOI:
EISSN:
1474-4465
ISSN:
1474-4422
URN:
uuid:9cd75086-f3d0-44a9-b973-2ca7faa83399
Source identifiers:
465869
Local pid:
pubs:465869

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