Journal article icon

Journal article

Adeno-associated virus (AAV) dual vector strategies for gene therapy encoding large transgenes

Abstract:

The use of adeno-associated viral (AAV) vectors for gene therapy treatments of inherited disorders has accelerated over the past decade with multiple clinical trials ongoing in varying tissue types and new ones initiating every year. These vectors are exhibiting low-immunogenicity across the clinical trials in addition to showing evidence of efficacy, making it clear they are the current standard vector for any potential gene therapy treatment. However, AAV vectors do have a limitation in the...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
More from this funder
Grant:
DPFS/DCS Research Grant MR/K007629/1
Publisher:
Yale University Publisher's website
Journal:
Yale Journal of Biology and Medicine Journal website
Volume:
90
Issue:
4
Pages:
611-623
Publication date:
2017-12-19
Acceptance date:
2017-12-15
ISSN:
0044-0086
Pubs id:
pubs:815179
URN:
uri:9cd3f03f-6dd5-41b4-9d27-e5c3d79e4956
UUID:
uuid:9cd3f03f-6dd5-41b4-9d27-e5c3d79e4956
Local pid:
pubs:815179

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP