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Macrophage-based anti-cancer therapy: modelling different modes of tumour targeting.

Abstract:

Tumour hypoxia is associated with poor drug delivery and low rates of cell proliferation, factors that limit the efficacy of therapies that target proliferating cells. Since macrophages localise within hypoxic regions, a promising way to target hypoxic tumour cells involves engineering macrophages to express therapeutic genes under hypoxia. In this paper we develop mathematical models to compare the responses of avascular tumour spheroids to two modes of action: either the macrophages deliver...

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Publication status:
Published

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Publisher copy:
10.1007/s11538-006-9189-2

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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
Journal:
Bulletin of mathematical biology
Volume:
69
Issue:
5
Pages:
1747-1776
Publication date:
2007-07-05
DOI:
EISSN:
1522-9602
ISSN:
0092-8240
URN:
uuid:9cad1148-cb5c-4137-bf0e-5c6d9284a09d
Source identifiers:
319104
Local pid:
pubs:319104

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