Journal article
Macrophage-based anti-cancer therapy: modelling different modes of tumour targeting.
- Abstract:
-
Tumour hypoxia is associated with poor drug delivery and low rates of cell proliferation, factors that limit the efficacy of therapies that target proliferating cells. Since macrophages localise within hypoxic regions, a promising way to target hypoxic tumour cells involves engineering macrophages to express therapeutic genes under hypoxia. In this paper we develop mathematical models to compare the responses of avascular tumour spheroids to two modes of action: either the macrophages deliver...
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- Publication status:
- Published
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- Publisher copy:
- 10.1007/s11538-006-9189-2
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Authors
Bibliographic Details
- Journal:
- Bulletin of mathematical biology
- Volume:
- 69
- Issue:
- 5
- Pages:
- 1747-1776
- Publication date:
- 2007-07-01
- DOI:
- EISSN:
-
1522-9602
- ISSN:
-
0092-8240
- Source identifiers:
-
319104
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:319104
- UUID:
-
uuid:9cad1148-cb5c-4137-bf0e-5c6d9284a09d
- Local pid:
- pubs:319104
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2007
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