- Abstract:
-
Tumour hypoxia is associated with poor drug delivery and low rates of cell proliferation, factors that limit the efficacy of therapies that target proliferating cells. Since macrophages localise within hypoxic regions, a promising way to target hypoxic tumour cells involves engineering macrophages to express therapeutic genes under hypoxia. In this paper we develop mathematical models to compare the responses of avascular tumour spheroids to two modes of action: either the macrophages deliver...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/s11538-006-9189-2
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- Journal:
- Bulletin of mathematical biology
- Volume:
- 69
- Issue:
- 5
- Pages:
- 1747-1776
- Publication date:
- 2007-07-05
- DOI:
- EISSN:
-
1522-9602
- ISSN:
-
0092-8240
- URN:
-
uuid:9cad1148-cb5c-4137-bf0e-5c6d9284a09d
- Source identifiers:
-
319104
- Local pid:
- pubs:319104
- Copyright date:
- 2007
Journal article
Macrophage-based anti-cancer therapy: modelling different modes of tumour targeting.
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