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Topological defects in epithelia govern cell death and extrusion

Abstract:

Epithelial tissues (epithelia) remove excess cells through extrusion, preventing the accumulation of unnecessary or pathological cells. The extrusion process can be triggered by apoptotic signalling1, oncogenic transformation2, 3 and overcrowding of cells4, 5, 6. Despite the important linkage of cell extrusion to developmental7, homeostatic5 and pathological processes2, 8 such as cancer metastasis, its underlying mechanism and connections to the intrinsic mechanics of the epithelium are large...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/nature21718

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Department:
Oxford, MPLS, Physics, Theoretical Physics
Kocgozlu, L More by this author
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Department:
Oxford, MPLS, Physics, Theoretical Physics
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Journal website
Volume:
544
Issue:
7649
Pages:
212-216
Publication date:
2017-04-12
Acceptance date:
2017-02-22
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pubs id:
pubs:686312
URN:
uri:9c7b398a-90d8-4185-9830-26fb8625ed75
UUID:
uuid:9c7b398a-90d8-4185-9830-26fb8625ed75
Local pid:
pubs:686312

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