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Targeting free prostate-specific antigen for in vivo imaging of prostate cancer using a monoclonal antibody specific for unique epitopes accessible on free prostate-specific antigen alone.

Abstract:

This study investigated the feasibility of targeting the free, unbound forms of prostate-specific antigen (fPSA) for in vivo imaging of prostate adenocarcinomas (PCa), as PSA is produced and secreted at abundance during every clinical stage and grade of PCa, including castration-resistant disease. We injected (125)I-labeled monoclonal antibody PSA30 (specific for an epitope uniquely accessible on fPSA alone) intravenously in male nude mice carrying subcutaneous xenografts of LNCaP tumors (n=3...

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Publisher copy:
10.1089/cbr.2011.1088

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Journal:
Cancer biotherapy and radiopharmaceuticals
Volume:
27
Issue:
4
Pages:
243-251
Publication date:
2012-05-05
DOI:
EISSN:
1557-8852
ISSN:
1084-9785
URN:
uuid:9c40dfdf-ea35-4d99-a8fb-025178b513e3
Source identifiers:
365859
Local pid:
pubs:365859

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