- Abstract:
-
This study investigated the feasibility of targeting the free, unbound forms of prostate-specific antigen (fPSA) for in vivo imaging of prostate adenocarcinomas (PCa), as PSA is produced and secreted at abundance during every clinical stage and grade of PCa, including castration-resistant disease. We injected (125)I-labeled monoclonal antibody PSA30 (specific for an epitope uniquely accessible on fPSA alone) intravenously in male nude mice carrying subcutaneous xenografts of LNCaP tumors (n=3...
Expand abstract - Publisher copy:
- 10.1089/cbr.2011.1088
-
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- Journal:
- Cancer biotherapy and radiopharmaceuticals
- Volume:
- 27
- Issue:
- 4
- Pages:
- 243-251
- Publication date:
- 2012-05-05
- DOI:
- EISSN:
-
1557-8852
- ISSN:
-
1084-9785
- URN:
-
uuid:9c40dfdf-ea35-4d99-a8fb-025178b513e3
- Source identifiers:
-
365859
- Local pid:
- pubs:365859
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Targeting free prostate-specific antigen for in vivo imaging of prostate cancer using a monoclonal antibody specific for unique epitopes accessible on free prostate-specific antigen alone.
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