Journal article icon

Journal article

Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo.

Abstract:

Bisphosphonates are widely used antiresorptive drugs that bind to calcium. It has become evident that these drugs have differing affinities for bone mineral; however, it is unclear whether such differences affect their distribution on mineral surfaces. In this study, fluorescent conjugates of risedronate, and its lower-affinity analogues deoxy-risedronate and 3-PEHPC, were used to compare the localization of compounds with differing mineral affinities in vivo. Binding to dentine in vitro conf...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/jbmr.1543

Authors


Roelofs, AJ More by this author
Stewart, CA More by this author
Błażewska, KM More by this author
Kashemirov, BA More by this author
Expand authors...
Journal:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume:
27
Issue:
4
Pages:
835-847
Publication date:
2012-04-05
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
URN:
uuid:9c3cfccc-4dd0-47a2-9fb8-e4121afb0cbd
Source identifiers:
322736
Local pid:
pubs:322736

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP