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Journal article

The importance of Ca(2+)-dependent mechanisms for the initiation of the heartbeat.

Abstract:

Mechanisms underlying pacemaker activity in the sinus node remain controversial, with some ascribing a dominant role to timing events in the surface membrane ("membrane clock") and others to uptake and release of calcium from the sarcoplasmic reticulum (SR) ("calcium clock"). Here we discuss recent evidence on mechanisms underlying pacemaker activity with a particular emphasis on the many roles of calcium. There are particular areas of controversy concerning the contribution of calcium spark-...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fphys.2015.00080

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
British Heart Foundation More from this funder
Wellcome Trust More from this funder
Publisher:
Frontiers Publisher's website
Journal:
Frontiers in physiology Journal website
Volume:
6
Issue:
MAR
Pages:
80
Publication date:
2015
DOI:
EISSN:
1664-042X
ISSN:
1664-042X
URN:
uuid:9c2186f3-8f41-453c-8d4e-b2dc96765cac
Source identifiers:
518587
Local pid:
pubs:518587

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