Journal article
A population dynamics model of cell-cell adhesion incorporating population pressure and density saturation
- Abstract:
- We discuss several continuum cell-cell adhesion models based on the underlying microscopic assumptions. We propose an improvement on these models leading to sharp fronts and intermingling invasion fronts between different cell type populations. The model is based on basic principles of localized repulsion and nonlocal attraction due to adhesion forces at the microscopic level. The new model is able to capture both qualitatively and quantitatively experiments by Katsunuma et al. (2016). We also review some of the applications of these models in other areas of tissue growth in developmental biology. We finally explore the resulting qualitative behavior due to cell-cell repulsion.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 2.9MB, Terms of use)
-
- Publisher copy:
- 10.1016/j.jtbi.2019.04.023
Authors
- Publisher:
- Elsevier
- Journal:
- Journal of Theoretical Biology More from this journal
- Volume:
- 474
- Pages:
- 14-24
- Publication date:
- 2019-05-03
- Acceptance date:
- 2019-04-29
- DOI:
- EISSN:
-
1095-8541
- ISSN:
-
0022-5193
- Pmid:
-
31059713
- Language:
-
English
- Keywords:
- Pubs id:
-
1098224
- Local pid:
-
pubs:1098224
- Deposit date:
-
2020-04-07
- ARK identifier:
Terms of use
- Copyright holder:
- Elsevier Ltd
- Copyright date:
- 2019
- Rights statement:
- © 2019 Elsevier Ltd.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Elsevier at https://doi.org/10.1016/j.jtbi.2019.04.023
If you are the owner of this record, you can report an update to it here: Report update to this record