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MHC class II proteins and disease: a structural perspective

Abstract:

MHC class II molecules on the surface of antigen-presenting cells display a range of peptides for recognition by the T-cell receptors of CD4⁺ T helper cells. Therefore, MHC class II molecules are central to effective adaptive immune responses, but conversely, genetic and epidemiological data have implicated these molecules in the pathogenesis of autoimmune diseases. Indeed, the strength of the associations between particular MHC class II alleles and disease render them the main genetic risk f...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nri1805

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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Division of Structural Biology
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Institution:
"Aarhus University Hospital, Aarhus, Denmark", "University of Oxford"
Research group:
MRC Human Immunology Unit
Department:
Medical Sciences Division - Molecular Medicine,Weatherall Institute of
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Institution:
Harvard University, Cambridge, Massachusetts, USA
Department:
Department of Molecular and Cellular Biology
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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Division of Structural Biology
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Funding agency for:
E. Yvonne Jones
Danish Medical Research Council More from this funder
British Medical Research Council More from this funder
Cancer Research UK More from this funder
Karen Elise Jensen Foundation More from this funder
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Publisher:
Macmillan Publishers Ltd. Publisher's website
Journal:
Nature Reviews Immunology Journal website
Volume:
6
Pages:
271-282
Publication date:
2006-04-05
DOI:
EISSN:
1474-1741
ISSN:
1474-1733
URN:
uuid:9bf1ab7c-f90f-4f02-af0a-e03f9680d11e
Local pid:
ora:5272
Language:
English
Subjects:

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