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Cytotoxic T cells in HIV2 seropositive Gambians. Identification of a virus-specific MHC-restricted peptide epitope.

Abstract:

A preliminary study of gag-specific, MHC-restricted CD8+ CTL has been performed in nine Gambian patients infected with HIV2. Such CTL were present in at least 55% of patients in fresh peripheral blood mononuclear cells without the requirement for in vitro restimulation. We have identified a nonamer peptide from HIV2 gag that is recognized by CD8+ HLA-B53 CTL using an amino acid sequence motif predicted from analysis of endogenous peptides eluted from HLA-B53 molecules. This peptide, from an H...

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Publication status:
Published

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Journal:
Journal of Immunology
Volume:
151
Issue:
6
Pages:
3361-3369
Publication date:
1993-09-01
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
35663

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