- Abstract:
-
Amyotrophic lateral sclerosis is a devastating neurodegenerative disorder characterized by the progressive loss of spinal motor neurons. While the aetiological mechanisms underlying the disease remain poorly understood, oxidative stress is a central component of amyotrophic lateral sclerosis and contributes to motor neuron injury. Recently, oxidation resistance 1 (OXR1) has emerged as a critical regulator of neuronal survival in response to oxidative stress, and is upregulated in the spinal c...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 1.6MB)
-
- Publisher copy:
- 10.1093/brain/awv039
-
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- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Brain Journal website
- Volume:
- 138
- Issue:
- 5
- Pages:
- 1167-1181
- Publication date:
- 2015-03-09
- Acceptance date:
- 2014-12-23
- DOI:
- ISSN:
-
1460-2156
- Pubs id:
-
pubs:510147
- URN:
-
uri:9bdcf6bd-bfe5-4ce1-99a1-f362dde33c0d
- UUID:
-
uuid:9bdcf6bd-bfe5-4ce1-99a1-f362dde33c0d
- Local pid:
- pubs:510147
- Language:
- English
- Keywords:
- Copyright holder:
- Liu et al.
- Copyright date:
- 2015
- Notes:
- © The Author (2015). Published by Oxford University Press on behalf of the Guarantors of Brain. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal article
Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis
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