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Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis

Abstract:

Amyotrophic lateral sclerosis is a devastating neurodegenerative disorder characterized by the progressive loss of spinal motor neurons. While the aetiological mechanisms underlying the disease remain poorly understood, oxidative stress is a central component of amyotrophic lateral sclerosis and contributes to motor neuron injury. Recently, oxidation resistance 1 (OXR1) has emerged as a critical regulator of neuronal survival in response to oxidative stress, and is upregulated in the spinal c...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/brain/awv039

Authors


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Role:
Author
ORCID:
0000-0003-2071-5137
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
ORCID:
0000-0002-0152-3642
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
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Grant:
090532
090532/Z/09/Z
Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
138
Issue:
5
Pages:
1167-1181
Publication date:
2015-03-09
Acceptance date:
2014-12-23
DOI:
ISSN:
1460-2156
Pubs id:
pubs:510147
URN:
uri:9bdcf6bd-bfe5-4ce1-99a1-f362dde33c0d
UUID:
uuid:9bdcf6bd-bfe5-4ce1-99a1-f362dde33c0d
Local pid:
pubs:510147

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