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Longitudinal quantitative proton magnetic resonance spectroscopy of the hippocampus in Alzheimer's disease.

Abstract:

Changes in metabolites detected by proton magnetic resonance spectroscopy ((1)H MRS) of the brain have been demonstrated in Alzheimer's disease. Our objectives were, first, longitudinally to measure absolute concentrations of metabolites in both hippocampi, the sites of early Alzheimer's disease, in patients with clinical Alzheimer's disease and controls; secondly, to separate the relative contribution of atrophy and metabolite concentration change to overall signal change; and, thirdly, to d...

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Publication status:
Published

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Publisher copy:
10.1093/brain/awf226

Authors


Bradley, KM More by this author
Journal:
Brain : a journal of neurology
Volume:
125
Issue:
Pt 10
Pages:
2332-2341
Publication date:
2002-10-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:9b9d9e87-ea8f-4edd-abf9-a7adc6747bbb
Source identifiers:
195478
Local pid:
pubs:195478

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