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Journal article

Repurposing of potent drug candidates for multiparasite targeting

Abstract:
Parasite-directed drug discovery efforts require sustained and substantial scientific resources. Many eukaryotic parasites share similarities in metabolic pathways and housekeeping genes, as evident from their underlying protein sequences. Their subsequent structural congruence within enzyme active sites can thus be leveraged for multiparasite targeting using similar or identical drug probes. This bodes well for delivering new anti-infectives.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.pt.2016.12.007

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author


Publisher:
Cell Press
Journal:
Trends in Parasitology More from this journal
Volume:
33
Issue:
3
Pages:
158-161
Publication date:
2017-01-09
Acceptance date:
2016-01-01
DOI:
EISSN:
1471-5007
ISSN:
1471-4922


Pubs id:
pubs:697690
UUID:
uuid:9b71b01b-5ac0-40fc-98f3-421b07382b20
Local pid:
pubs:697690
Source identifiers:
697690
Deposit date:
2017-05-30

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