Journal article
Spatial and temporal distribution of information processing in the human dorsal anterior cingulate cortex
- Abstract:
- The dorsal anterior cingulate cortex (dACC) is a key node in the human salience network. It has been ascribed motor, pain-processing and affective functions. However, the dynamics of information flow in this complex region and how it responds to inputs remain unclear and are difficult to study using non-invasive electrophysiology. The area is targeted by neurosurgery to treat neuropathic pain. During deep brain stimulation surgery, we recorded local field potentials from this region in humans during a decision-making task requiring motor output. We investigated the spatial and temporal distribution of information flow within the dACC. We demonstrate the existence of a distributed network within the anterior cingulate cortex where discrete nodes demonstrate directed communication following inputs. We show that this network anticipates and responds to the valence of feedback to actions. We further show that these network dynamics adapt following learning. Our results provide evidence for the integration of learning and the response to feedback in a key cognitive region.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 5.0MB, Terms of use)
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- Publisher copy:
- 10.3389/fnhum.2022.780047
Authors
- Publisher:
- Frontiers Media
- Journal:
- Frontiers in Human Neuroscience More from this journal
- Volume:
- 16
- Article number:
- 780047
- Publication date:
- 2022-03-18
- Acceptance date:
- 2022-02-18
- DOI:
- EISSN:
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1662-5161
- Language:
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English
- Keywords:
- Pubs id:
-
1249655
- Local pid:
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pubs:1249655
- Deposit date:
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2022-04-07
- ARK identifier:
Terms of use
- Copyright holder:
- Keogh et al.
- Copyright date:
- 2022
- Rights statement:
- Copyright © 2022 Keogh, Deli, Zand, Zorman, Boccard-Binet, Parrott, Sigalas, Weiss, Stein, FitzGerald, Aziz, Green and Gillies. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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