Journal article
Adjunctive benzodiazepines in depression: a clinical dilemma with no recent answers from research
- Abstract:
- Comorbid anxiety symptoms are common in depression, and adding benzodiazepines to antidepressant treatment may seem a rational clinical solution. Benzodiazepines also have potential to reduce the initial anxiety that may be caused by early antidepressant treatment (owing to their inhibitory effect via GABAA receptor binding). This month's Cochrane Corner review examines the evidence behind combination treatment versus antidepressants alone in major depressive disorder, in terms of both the clinical and neuroscientific context. The review provides evidence that, in the first 4 weeks of treatment, additional medication with a benzodiazepine may lead to greater improvements than antidepressant alone on ratings of severity, response rates and remission rates for depression, but not on measures of anxiety.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 350.6KB, Terms of use)
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- Publisher copy:
- 10.1192/bja.2020.17
Authors
- Publisher:
- Cambridge University Press
- Journal:
- BJPsych Advances More from this journal
- Volume:
- 26
- Issue:
- 6
- Pages:
- 321-326
- Publication date:
- 2020-10-30
- Acceptance date:
- 2020-02-24
- DOI:
- EISSN:
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2056-4686
- ISSN:
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2056-4678
- Language:
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English
- Keywords:
- Pubs id:
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1090948
- Local pid:
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pubs:1090948
- Deposit date:
-
2020-03-04
Terms of use
- Copyright holder:
- De Cates and De Giorgi
- Copyright date:
- 2020
- Rights statement:
- Copyright © The Authors 2020
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Cambridge University Press at: https://doi.org/10.1192/bja.2020.17
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