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Low-dose phase retrieval of biological specimens using cryo-electron ptychography

Abstract:

Cryo-electron microscopy is an essential tool for high-resolution structural studies of biological systems. This method relies on the use of phase contrast imaging at high defocus to improve information transfer at low spatial frequencies at the expense of higher spatial frequencies. Here we demonstrate that electron ptychography can recover the phase of the specimen with continuous information transfer across a wide range of the spatial frequency spectrum, with improved transfer at lower spa...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MPLS
Department:
Materials
Role:
Author
ORCID:
0000-0003-1513-9964
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Materials
Role:
Author
ORCID:
0000-0002-7864-8427
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
11
Issue:
1
Article number:
2773
Place of publication:
England
Publication date:
2020-06-02
Acceptance date:
2020-04-28
DOI:
EISSN:
2041-1723
Pmid:
32487987
Pubs id:
1108475
Local pid:
pubs:1108475
Language:
English
Keywords:
Format:
Electronic

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