Hematological features of patients with myelodysplastic syndromes associated with a chromosome 5q deletion.

Journal article

The hematological and clinical features of 26 patients with myelodysplasia and a chromosome 5q deletion in the bone marrow are presented. We have examined the relationship of French-American-British Co-operative Group (FAB) 1982 classification and bone marrow karyotype at diagnosis with patient outcome and the presence or absence of the classical features of the 5q-syndrome. Those patients classified as refractory anemia (RA) with no additional karyotypic abnormalities have the typical features of the 5q-syndrome and a good prognosis. None of the patients in this group transformed to acute leukemia during the period of follow-up. Patients with either refractory anemia and excess blasts (RAEB) or additional karyotypic abnormalities show many of the hematologic features of the 5q-syndrome but do not share the good prognosis. We conclude that the 5q-syndrome may be best defined as primary MDS of the FAB type RA with a 5q deletion as the sole karyotypic abnormality. This simple definition will distinguish patients with a good prognosis and all the classical features of the 5q-syndrome.

Authors: Lewis, S; Oscier, D; Boultwood, J; Ross, F; Fitchett, M

• Publication status: Published
• Journal: American journal of hematology
• Volume: 49
• Issue: 3
• Pages: 194-200
• Publication date: 1995-07-01
• DOI: 10.1002/ajh.2830490304
• EISSN: 1096-8652
• ISSN: 0361-8609
• Language: English
• Keywords: Aged, 80 and over; Adult; Gene Deletion; Prognosis; Chromosomes, Human, Pair 5; Male; Anemia, Refractory; Aged; Acute Disease; Bone Marrow; Leukemia; Karyotyping; Myelodysplastic Syndromes; Middle Aged; Female; Anemia, Refractory, with Excess of Blasts; Humans