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A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A.

Abstract:

Human genetic variation contributes to differences in susceptibility to HIV-1 infection. To search for novel host resistance factors, we performed a genome-wide association study (GWAS) in hemophilia patients highly exposed to potentially contaminated factor VIII infusions. Individuals with hemophilia A and a documented history of factor VIII infusions before the introduction of viral inactivation procedures (1979-1984) were recruited from 36 hemophilia treatment centers (HTCs), and their gen...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddt033

Authors


McLaren, PJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Shianna, KV More by this author
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Journal:
Human molecular genetics
Volume:
22
Issue:
9
Pages:
1903-1910
Publication date:
2013-05-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:9ae53b5f-adf8-4997-9d6f-8036f2938b48
Source identifiers:
396044
Local pid:
pubs:396044

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