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Journal article

Structure of an Hsp90-Cdc37-Cdk4 complex.

Abstract:

Activation of many protein kinases depends on their interaction with the Hsp90 molecular chaperone system. Recruitment of protein kinase clients to the Hsp90 chaperone system is mediated by the cochaperone adaptor protein Cdc37, which acts as a scaffold, simultaneously binding protein kinases and Hsp90. We have now expressed and purified an Hsp90-Cdc37-Cdk4 complex, defined its stoichiometry, and determined its 3D structure by single-particle electron microscopy. Comparison with the crystal s...

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Publication status:
Published

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Journal:
Molecular cell
Volume:
23
Issue:
5
Pages:
697-707
Publication date:
2006-09-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:9ae2ba93-f29b-4a4a-9ccd-cc890539e707
Source identifiers:
59423
Local pid:
pubs:59423

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