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HLA-associated polymorphisms in the HIV-2 capsid highlight key differences between HIV-1 and HIV-2 immune adaptation

Abstract:

Objective: HIV-1 frequently adapts in response to immune pressure from cytotoxic T-lymphocytes (CTL). Many HIV-2 infected individuals have robust capsid-specific CTL responses associated with viral control. Despite this CTL pressure, adaptive changes in this key immunogenic HIV-2 protein have not previously been described. We sought to compare selective pressure on HIV-1 and HIV-2 capsids and identify HLA-associated viral polymorphisms in HIV-2.

Design and methods: Bi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Version of record

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Publisher copy:
10.1097/qad.0000000000001753

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Role:
Author
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Publisher:
Lippincott, Williams & Wilkins Publisher's website
Journal:
AIDS Journal website
Publication date:
2018-03-27
Acceptance date:
2017-12-18
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
Pubs id:
pubs:823232
URN:
uri:9adce5c1-c140-4ae7-90c7-07a2d6ead08d
UUID:
uuid:9adce5c1-c140-4ae7-90c7-07a2d6ead08d
Local pid:
pubs:823232
Language:
English
Keywords:

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