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Oncolytic adenovirus expressing bispecific antibody targets T‐cell cytotoxicity in cancer biopsies

Abstract:

Oncolytic viruses exploit the cancer cell phenotype to complete their lytic life cycle, releasing progeny virus to infect nearby cells and repeat the process. We modified the oncolytic group B adenovirus EnAdenotucirev (EnAd) to express a bispecific single-chain antibody, secreted from infected tumour cells into the microenvironment. This bispecific T-cell engager (BiTE) binds to EpCAM on target cells and cross-links them to CD3 on T cells, leading to clustering and activation of both CD4 and...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.15252/emmm.201707567

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Department:
Oxford, MSD, Oncology
Role:
Author
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Department:
Oxford, MSD, Oncology
Role:
Author
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Department:
Oxford, MSD, Oncology
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Author
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Medical Research Council More from this funder
Publisher:
EMBO Press Publisher's website
Journal:
EMBO Molecular Medicine Journal website
Volume:
9
Issue:
8
Pages:
1067-1087
Publication date:
2017-06-20
Acceptance date:
2017-05-18
DOI:
ISSN:
1757-4684
Pubs id:
pubs:709218
URN:
uri:9ac9c645-775c-4daf-b003-7156998e3db3
UUID:
uuid:9ac9c645-775c-4daf-b003-7156998e3db3
Local pid:
pubs:709218
Paper number:
8

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