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Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod.

Abstract:

cMyBP-C [cardiac (MyBP-C) myosin-binding protein-C)] is a sarcomeric protein involved both in thick filament structure and in the regulation of contractility. It is composed of eight IgI-like and three fibronectin-3-like domains (termed C0-C10). Mutations in the gene encoding cMyBP-C are a principal cause of HCM (hypertrophic cardiomyopathy). cMyBP-C binds to the LMM (light meromyosin) portion of the myosin rod via its C-terminal domain, C10. We investigated this interaction in detail to dete...

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Publication status:
Published

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Publisher copy:
10.1042/bj20061151

Authors


Flashman, E More by this author
Watkins, H More by this author
Redwood, C More by this author
Journal:
The Biochemical journal
Volume:
401
Issue:
1
Pages:
97-102
Publication date:
2007-01-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:9aad2cf1-2334-4cd2-91bd-3d882d400bdd
Source identifiers:
104227
Local pid:
pubs:104227

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