Controlled ovarian stimulation protocols for assisted reproduction: a network meta‐analysis

Journal article : Review

Background: Controlled ovarian stimulation (COS) is an essential step in most assisted conception cycles. Different treatment combinations (termed protocols) exist in COS, yet there is no consensus on their relative effectiveness and safety.

Objectives: We aimed to assess the relative effectiveness and safety of COS protocols in clinical practice.

Search methods: We followed standard Cochrane methodology to conduct extensive ...

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Authors: Melo, P; Eapen, A; Chung, Y; Jeve, Y; Price, MJ

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Cochrane Collaboration
• Journal: Cochrane Database of Systematic Reviews
• Volume: 2025
• Issue: 7
• Article number: cd012586
• Place of publication: England
• Publication date: 2025-07-01
• DOI: 10.1002/14651858.cd012586.pub2
• EISSN: 1469-493X
• ISSN: 1361-6137
• Pmid: 40590303
• Language: English
• Keywords: biomedical and clinical sciences; follicle stimulating hormone; pregnancy; multiple; live birth; clinical trials and supportive activities; clinical research; letrozole; clomiphene; randomized controlled trials as topic; progestins; fertility agents; female; pregnancy rate; abortion; spontaneous; reproductive health and childbirth; contraception/reproduction; ovulation induction; ovarian hyperstimulation syndrome; women's health; luteinizing hormone; bias; gonadotropin-releasing hormone; menotropins; reproductive techniques; assisted; infertility
• Subtype: Review