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Catalytic asymmetric alkylation reactions for the construction of protected ethylene-amino and propylene-amino motifs attached to quaternary stereocentres.

Abstract:

An efficient catalytic and stereoselective method for the direct construction of protected ethylene-amino and propylene-amino scaffolds attached to quaternary stereocentres is reported. Preliminary investigations revealed a mild base catalysed nucleophilic ring opening of N-sulfonyl aziridines using the commercially available phosphazene base 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine (BEMP) was possible and resulted in highly efficient alkylation reactions ...

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Publication status:
Published

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Publisher copy:
10.1002/chem.201203825

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Chemistry (Weinheim an der Bergstrasse, Germany)
Volume:
19
Issue:
9
Pages:
3071-3081
Publication date:
2013-02-05
DOI:
EISSN:
1521-3765
ISSN:
0947-6539
URN:
uuid:9a971f3a-5657-41b4-a438-99d118fab35a
Source identifiers:
375684
Local pid:
pubs:375684

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